Fronting a ten-piece band that augmented his regular musicians with a full brass section and backing singers, Nutini, 27, was making his first public appearance since a show in the cultural programme around the London Olympics in the summer of 2012.
The Caustic Love album will not be released until days after the soulful singer-songwriter plays a homecoming concert at Glasgow Barrowland on March 29, but its songs are certain to fill the airwaves for much of the rest of the year.
It has been five years since the release of his last disc, Sunny Side Up, whose varied content surprised critics, but which went on to outsell his debut, These Streets. The new album continues that development, with the dancefloor-aimed first single, Scream (Funk My Life Up), being just one facet of its styles.
Rapper Angel Haze joined the singer onstage for the newest track, Fashion, which consciously references the David Bowie song of the same name.
Nutini added vocal samples from movies to the mix from a keyboard at his side, including an excerpt from a famous speech in Charlie Chaplin's 1940 classic The Great Dictator in the new song Iron Sky.