The cookery star will appear alongside Gary Barlow and adventurer Bear Grylls in the fourth episode of The Michael McIntyre Chat Show.
Singer Gary will chat about his new tour and single, while Nigella will have a "foodie chat around her latest series of books" in the episode screened on BBC One on Monday March 31.
Nigella previously appeared on US TV after her personal assistants were cleared of fraud in a trial which depicted the TV cook, who was a witness in the case, as a cocaine user.
During her testimony in December, Nigella admitted taking the drug in the past but denied being an addict.
Nigella told Good Morning America: " To have not only your private life but distortions of your private life put on display is mortifying, but there are people going through an awful lot worse."
"To dwell on any of it would be self pity, and I don't like to do that."