Around 100 of his paintings go on display at Glasgow's Kelvingrove Art Gallery and Museum tomorrow.
All of the artist's best-known works, including The Singing Butler and Dance Me To The End Of Love, have been brought together for the first time.
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Speaking at the gallery, Mr Vettriano said seeing all his paintings gathered in one exhibition is "indescribable".
He said: "If it was just me here, it would bring a tear to my eye. I never thought this would happen.
"There have been several critics in Scotland who have been particularly unkind, but at least I have tried and I have put my work up and I'll let people judge it for themselves. So, there is a small sense of satisfaction.
"There will be people out there that will come through and have a good laugh at it all and not enjoy it. They don't interest me a bit. I'm far more interested in the public that come through here and leave feeling much better about themselves and about life.
"They are seeing 20 years of an artist who started off just hoping that he could make a living painting and who has become quite well known."
Looking back at his 1992 painting The Singing Butler, he said: "I think that painting was ahead of its time. I shouldn't have been able to paint it but I was able to do it.
"Of course, we all know the controversy about it. I picked photographs out of a book but that was what the book was meant for. It was meant for folk who don't have access to models.
"The same book was found in Francis Bacon's studio. If it was good enough for Francis, it was good enough for me."
A range of Vettriano's less familiar paintings are also on show, including rarely-seen early works, self-portraits and special commissions.
Jack Vettriano: A Retrospective Exhibition runs until February 23.