The group, which supplies supermarkets with own-brand products from shower gels to dishwasher tablets, said it was leading a review of its UK operations that was likely to lead to a "significant restructuring of our activities, including capacity reduction".
It will give more details in its next trading statement in June.
McBride employs around 2,000 staff in the UK out of a 5,000 overall workforce and has factories at Barrow in Cumbria, Bradford, Hull and Middleton, near Manchester, where it is also headquartered.
It has a further 13 plants across southeast Asia and Europe.
The group, which makes Oven Pride cleaner, unveiled its restructuring plans as it said annual profits for the year to the end of June were set to miss forecasts.
Revenues have fallen 4% year-on-year since the beginning of January, with private label sales 2% lower due to an "extraordinarily weak retail environment" in the UK and Italy.
Intense competition and promotional activity has also hit trading, it added.
The group warned over first half profits in January due to the competitive conditions in the UK, reporting an 11% drop in interim underlying earnings a month later.
McBride said today it expects an improvement in trading over its final quarter thanks to product launches, but said this would be offset by the tough UK and Italian trading conditions.
Shares plunged 10% after its profit alert.
The firm was founded by Robert McBride in 1927 in north Manchester to supply chemical processing products to Lancashire's cotton industry.