The event, in association with Enigma People Solutions, Jumpstart UK, metadigital, University of Glasgow and Hillington Park Innovation Centre, covers many parts of the industry, including social media, app development and marketing.
Entries can be made via www.herald-events.com/digitalawards with nominations open until September 4.
David Mains, director of Enigma People Solutions, said: "Digital businesses are major employers and contributors to our economy in Scotland and an important part of our future. We are very much looking forward to celebrating every entrant's achievements."
The event takes place on October 23.