The California company, which makes equipment and software for cloud computing networks and data centres, says it plans to shed 5% of its global workforce in spite of fourth quarter profits rising from $1.9 billion to $2.3bn and a 6% increase in revenue to $12.4bn.
It employs around 150 in Scotland with many based at the Eurocentral business park.
However, the Nasdaq-listed business refused to say whether any Scottish posts were under threat.
A spokesman at Cisco said: "In the past two years we have managed the business with discipline and focus.
"In order to execute on the portfolio investment and operational efficiency opportunities we see in FY14, we are rebalancing our resources."
Chief executive John Chambers said conditions were improving but warned of weakness in Asia and mixed results in Europe.