The City remained unconvinced on Tesco's £1 billion turnaround plan while there was also a warning from Standard Chartered that it could be headed for its first drop in profits in a decade.
The supermarket giant posted lacklustre quarterly figures while the bank said operations in Asia were going to drag on profit.
RC Brown Investment Management's Andrew Morris: "You've had currency go against them and the picture in the Far East remains complicated. The argument for investing in Standard Chartered isn't as compelling as it was six months ago."
The FTSE fall comes after the London top tier lost more than 100 points on Monday and Tuesday.
There were also further falls across Europe after confirmation that the eurozone's recovery weakened with slower growth of 0.1% in the last quarter.
UK figures also revealed that there had been weaker-than-expected growth within the UK services sector.
The reading of 60 in the closely watched Markit/CIPS purchasing managers' index was well ahead of the 50 no-change level but down on the previous month's 16-year record of 62.5.
Tesco was near the top of the FTSE-100 risers board for a while, but later stood 1.6p lower at 340p amid a mixed reaction to its third quarter figures.
Shore Capital analyst Clive Black kept his buy rating on the stock and urged Tesco chief executive Philip Clarke to stick to his guns.
Retail and accountancy software group Sage topped the risers board in London with a gain of 7%, or 25.5p to 372.9p.
The company impressed the City with a small rise in full-year underlying profits and said it remained on track to achieve its 6% organic revenue growth target for 2015.
Asia-focused bank Standard Chartered led the fallers after it said it continued to face difficult trading conditions, with income this year likely to be flat on the performance in 2012.
The London headquartered bank, which declined 92.5p to 1338.5p, has been impacted by the weakness of local currencies against the US dollar.
Other fallers included Nurofen and Calgon owner Reckitt Benckiser after UBS cut its rating on the stock from buy to sell. Shares have enjoyed a strong run since October but were down 49p to 4816p yesterday.
The biggest FTSE-100 risers were Sage Group ahead 25.5p to 372.9p, Tullow Oil up 22p to 876p, Melrose Industries 7.1p higher at 287.4p and Rio Tinto 62.5p stronger at 3262.5p.
The biggest FTSE-100 fallers were Standard Chartered down 92.5p to 1338.5p, Aberdeen Asset Management off 22.3p to 461.4p, Pearson 37p lower at 1295p and Severn Trent 40p weaker at 1663p.