The Bradford-based retailer will update on its roll out of M-Local convenience stores as it attempts to halt falling sales.
Morrisons saw like-for-like sales fall 1.8% in the three months to May 5.
Analysts on average expect pre-tax profits for the six months to the start of August to slide 13% to £383 million from £440m a year earlier, with underlying profits falling 8% to £410m.
John Lewis is set to post more strong growth as its department stores and Waitrose supermarkets thrive on a recovering retail picture.
Retail analyst Nick Bubb expects the employee-owned group to post a rise in underlying pre-tax profits of around 6% to £117m in the six months to the end of July.