Scotland's desire for political and economic change has been heard and will be delivered, Ed Miliband will promise as he insists a "vote for No is a vote for change".
Returning to the referendum campaign trail, the Labour leader will insist that backing independence puts jobs, the economy and the NHS at risk and underline that the decision is irreversible.
He will promise that "things will not go back to the way things were" after Thursday and call on Scots to help lead reform of the British state.
During a visit to central Scotland, Mr Miliband is expected to say: "In the next 48 hours Scotland faces a historic decision which will shape its future and the whole of the UK's future for centuries to come.
"Down one path by rejecting separatism and voting No there is the promise of change. Change for a stronger Scotland and a better Britain.
"The will of the people of Scotland for economic and political change has been heard and we will deliver.
"Change is coming with more powers on tax and welfare for the Scottish Parliament.
"We will change the British state too, the House of Lords and the way we work together across our nations.
"I ask the people of Scotland to lead that change of our whole British constitution and I also ask them to help deliver economic change too with a Labour government in May 2015 - a government that is within our reach and just months away."
Mr Miliband will argue that the "great injustices" the nation faces today, such as low pay, unemployment and the gap between rich and poor, are better tackled together.
He will appeal to voters to keep the union together as well as help to install a Labour government at the general election next year.
"The great achievements of Britain over 300 years, from workers' rights to the NHS, will be matched as we tackle the great injustices of today," he will say.
"Injustices we can better surmount together. Together tackling poverty pay, together realising full employment, together taking on the vested interests from the banks to the energy companies, together replacing insecurity with security at work, together tackling the huge gap between rich and poor.
"These are the great causes of our time, together we will deliver and together we will build a stronger Scotland and a better Britain."
He will add: "On the other path of Yes is a future of separation and risk, an irreversible decision, a risk to jobs, the economy and the NHS, as we abandon the shared resources and redistribution of our United Kingdom.
"With a No vote, things will not go back to the way things were after Thursday.
"Scotland has shown why we must and why we will change our whole country. Scotland can lead that change across Britain.
"A vote for No is a vote for change. Let's take our chance to change our country together."
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