Functional foods could combat hereditary flaws

The success of functional foods, such as probiotic yoghurts and cholesterol-lowering margarines, has prompted scientists to pursue personalised diets to prevent disease, experts have revealed.

It is hoped the individually targeted diets, based on our genetic make-up, will tackle all manner of medical conditions from obesity, diabetes and intestinal diseases to cognitive failure, bone problems and even stress.

However, with obesity now the second biggest preventable killer disease after smoking, nutritionists are questioning whether the European Union's food research investment of 1.9 billion (£1.3bn) would be better spent on basic healthy eating education rather than on bio-technology and nutrigenomics.

Functional foods - foods perceived to have an added nutritional value - were worth £1.1bn by the end of 2005, having grown 143% since 2000. Dairy products such as spreads, yoghurts and probiotic drinks make up 45% of the sector, with Danone's Actimel the number one brand. Their growth has sparked a move to develop further links between medical science and diet.

Professor Charles Daly from the Alimentary Pharmabiotic Centre at University College Cork predicts by 2030 scientists will have a full understanding of our 25,000 genes and, through genetic sequencing, will be able to confirm specific dietary requirements.

"We can take a prevention rather than a treatment strategy," said Daly, "There is clearly an enhanced role for food in ensuring a better quality of life and a role for diet in preventing these diseases." Daly believes health and wellbeing are now a "significant driver" of the food industry. He added: "The challenge is to have those products maintaining their tastes and pleasurable effects. Some of the earlier attempts, like the so-called light products, didn't taste right so the consumer said no thanks'."

The Institute for Food Research (IFR) has been involved in a series of studies to fully determine the impact food compounds can have upon gene expression. IFR scientist John Eady said about 30% of genes show variations, signalling real potential to alter them through dietary intervention.

"The ultimate goal is personalised diets but that is a long way off. It is a multi- disciplinary sphere where you have influence of diet, lifestyle and age, so it's a real challenge to pick out the most important factors," said Eady. "That said, when I first started 20 years ago a whole PhD studied one gene. Now I run experiments where I look at 12,500 genes, doing the experiments in a couple of days."

Best-selling author of The Optimum Nutrition Bible, Patrick Holford, who is also CEO of the Food For The Brain Foundation, is concerned this scientific shift could prove dangerous. "Manipulating people's genes can help you fine tune your diet but I am deeply suspicious about what we are going to be able to do with any level of safety," said Holford.

"What is already clear from research is that most of the major killer diseases from which we suffer are clearly to do with our bad diet and lifestyle habits. The critical issue is how to effect change in the culture of 21st-century living."

Holford points to the mistake of promoting omega-3 enriched milk, with 10 pints needed to have the same health impact as a single piece of salmon. He urges the public to eat oats - more effective in controlling diabetes than the most commonly prescribed drug - and believes basic healthy eating education would make the biggest difference.

Holford added: "I don't mind a functional food. There is benefit in having a good balance of bacteria in the gut. Whether you need to consume bacteria every single day, usually in a small drink with three teaspoons of sugar in it at quite a large expense is, however, questionable.

"Rather than put money into how foods might modify our genes, we should spend it on changing the way people think about food. Most of us are digging our own graves with a knife and fork."