The school made famous by the film Gregory's Girl is to close.
Abronhill High School in Cumbernauld will be closed following a vote by North Lanarkshire councillors on its learning and leisure services committee.
Pupils will merge with those at Cumbernauld High School after the 2013/14 school year. They will all be taught at the Cumbernauld High School building until a new school is built.
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The school featured in the 1981 romantic comedy directed by Bill Forsyth and starring John Gordon Sinclair and Clare Grogan.
Scott Campbell, of the Save Abronhill High School campaign, said: "We are very disappointed and angry. We believe this decision is deeply flawed."
Despite a six-week consultation carried out by North Lanarkshire Council and campaigners suggesting alternatives to closure, the group believes no other options were given "serious consideration".
Mr Campbell said: "We will now be taking our case to the Scottish Government to request a call-in on the decision."
North Lanarkshire Council argues both schools are no longer fit for modern schooling and are hugely under-occupied.