The daughter of Tory former Cabinet minister Andrew Mitchell has called for Jeremy Hunt to be sacked over his handling of the junior doctor contract row.

Dr Hannah Mitchell accused the Health Secretary of misusing statistics and alienating "an entire generation" of her colleagues.

In a letter to The Guardian, Dr Mitchell wrote: "What Jeremy Hunt has managed to achieve is nothing short of spectacular.

"Health secretaries have come and gone, imposing new measures of varying unpopularity on the NHS but not one has managed to so completely unite doctors in their dislike and alienate healthcare workers across the board in the way he has.

"He says we lack vocation, he paints us as the problem. The morale of the workforce is at breaking point, with imposition the goodwill of doctors who work hours beyond those they are rota-ed and paid to do will dry up."

Dr Mitchell, who is likely to seek permanent work in South Africa after her research fellowship in Botswana and a posting in Sierra Leone, said her colleagues had been incensed by Mr Hunt's claim that the new contract was needed to avoid preventable deaths at the weekend.

"I am one of the many junior doctors who have left the UK. If he goes ahead with imposition of contract I am certainly unlikely to return to the UK to continue clinical practice," she added. "The Health Secretary has alienated an entire generation of junior doctors, we have no confidence in him, he must be sacked."

Former international development secretary Mr Mitchell, a long-standing friend of Mr Hunt, praised his daughter as a "fantastic doctor".

"There is no three-line whipping system in the Mitchell family," he said. "We are an open democracy and there is no dad in the country who is prouder of his daughters and the fantastic doctor that Hannah has become.

"Whatever the merits of this matter the junior hospital doctors are a dedicated, hard-working and inspiring group of people, although inevitably the Government is responsible for managing this resource."