Scotland's national poet, the Makar Jackie Kay, said that she felt "embarrassed to be British" after the European Referendum result.
The poet said on Twitter: "Woke up, slab of concrete across my chest embarrassed to be British but proud to be Scottish - feel like we're living in two countries" and later added that she was proud of First Minister Nicola Sturgeon's speech after the result became known.
Michael Ryan, chairman of the Independent Film & Television Alliance, said the vote was a "major blow" to the UK film industry.
He said: "The decision to exit the European Union is a major blow to the UK film and TV industry.
"Producing films and television programmes is a very expensive and very risky business and certainty about the rules affecting the business is a must.
"This decision has just blown up our foundation – as of today, we no longer know how our relationships with co-producers, financiers and distributors will work, whether new taxes will be dropped on our activities in the rest of Europe or how production financing is going to be raised without any input from European funding agencies.
"The UK creative sector has been a strong and vibrant contributor to the economy - this is likely to be devastating for us."
The Art Fund charity said it was "deeply concerned about what leaving... will mean for culture in the UK".
Fergus Linehan, the director of the Edinburgh International Festival, which was formed in 1947 as a reaction to the destruction of World War Two, said: "I have been thinking a lot about the rhetoric about the founding of the festival, which feels pertinent and urgent today.
"Although it does not effect what we are doing in the short term, it adds a degree of urgency to the 70 anniversary next year and revisiting the tenants on which the festival was constructed."
He said artistic colleagues in Europe had been "generally quite shocked" by the result.
Nick Barley, the director of the Edinburgh International Book Festival, said: “We are an international festival, and our ambition is to cross borders, cultures and societies through books, words and ideas.
" At this time of volatility not just in Europe but around the world, we need more than ever to provide a forum for international dialogue and understanding.
"Edinburgh’s role as a Festival City, which will mark 70 years in 2017, has never been more important.”
Philip Pullman, president of the Society of Authors, said he could not see "any good coming out of" the decision.
Janet Archer, the chief executive of Creative Scotland, the main funder of the arts north of the border, said: "The implications of the outcome of the EU Referendum will take time to unfold.
"However, we will continue to work with partners in Europe in many different ways.
"As set out in our 10 Year Plan, working internationally is an important part of what we do to ensure that Scotland remains a successful and distinctive creative nation connected to the world.
"Arts and culture transcend borders and bring people together from across the globe.
"We will continue to do everything we can to support our vibrant arts, screen and creative industries to make and sustain fruitful, positive international relationships across Europe and beyond."
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