Emma Wilson was responsible for inflicting a brain injury on her 11-month-old son Callum that resulted in blindness, multiple fractures and eventually his death.
Wilson, 25, from Windsor, Berkshire, had blamed her 23-month-old son for Callum's death, claiming "constant pushing and rolling" may have been to blame, the Old Bailey trial was told.
But a jury unanimously found her guilty last year and yesterday Judge Stephen Kramer, QC, sentenced her to life in prison with a minimum term of 14 years.
Callum died when he was taken from his mother's flat to hospital on March 18, 2011 in a "collapsed state", the court heard.
During the trial, prosecutor Paul Dunkels said Callum's brain injury was caused by a "direct blow" or from striking his head against something, while his leg fracture may have been the result of "banging against a hard surface".