The charges follow a police operation in Johnstone on Friday morning.
At about 7.05am, officers entered a house in Churchill Avenue in the town.
A spokeswoman for Police Scotland said officers recovered about 50kg of the drug Benzocaine and what is believed to be a further 4kgs of the stimulant Alpha PVT.
The drugs have an estimated street value of £160,000.
Three men, aged 16, 21, 57, and a 49-year-old woman, are currently in police custody in connection with the seizure and are expected to appear in Paisley Sheriff Court on Monday.