The city council's initiative has already identified nearly 350 fourth year pupils who failed to achieve five or more awards at foundation level Standard Grade in the 2012-13 school year's exams.
Officials asked secondaries to name the individuals and provide a report on why they had not achieved this basic set of qualifications.
Examples included many pupils who repeatedly refused to attend school, despite receiving support, often because of difficult family circumstances, such as parents who had been jailed.
In addition, there were a number of unusual cases. One involved a girl who neglected her school work after she became the main carer for her mother who became ill with cancer.
In another case, a pupil joined a secondary school from China and found it almost impossible to access the full curriculum because he spoke no English. However, he achieved both Standard Grade maths and Higher Mandarin.
One school, which had only two pupils who had not achieved the basic benchmark, said it had already adopted very close monitoring of individual pupils, particularly the most vulnerable, with targeted support, including getting them to school for important days.
"We will turn up on the morning of the exam and ferry the pupil in, but the real work is prior to the exam in ensuring that portfolios are in place," the school reported. The move comes as part of wider attempts by the city's education department to drive up standards.
It has traditionally had some of the lowest exam results in Scotland, but the city suffers significantly higher levels of deprivation than any other part of the country.
As numerous international studies have shown, deprivation is the single most significant barrier to attainment.
A report to the council by Maureen McKenna, executive director of education, states: "The exercise of gathering this data has heightened the importance of tracking vulnerable young people and for assessment information to be gathered from the earliest possible time to ensure young people achieve qualifications, even if their circumstances mean attendance at school becomes difficult.
"It has also shown that many of our schools go to extraordinary lengths to ensure as many young people as possible achieve qualifications."
Overall, Glasgow's results are improving and in some cases the increase in attainment is happening faster than across Scotland as a whole, where exam results have also improved.
The evidence from 2002/03 to 2011/12 shows a consistent improvement in the achievement of children from the 5% and 10% most deprived communities in Scotland, many of which are in Glasgow.
The sharpest improvement occurred in the performance of children from the most deprived communities. Stephen Curran, the council's spokesman for education, said: "We want every young person in the city to achieve to the very best of their ability. This is why we concentrated in tracking the young people in the city who do not achieve five or more Standard Grade awards.
"The analysis of the information has proved very interesting and will result in successful intervention and support for more vulnerable young people.
"Raising expectations is so important and is crucial to our ambition to drive up standards and the aspirations of pupils in all Glasgow schools."