Members of four unions - Unite, Unison, the University and College Union (UCU) and EIS in Scotland - are due to take part in the strike on Thursday, February 6.
Institutions across the UK could face disruption with lectures, seminars, workshops and tutorials cancelled or postponed as academics along with support staff such as technicians and administrators join picket lines.
University employers said they were disappointed another strike had been called, adding that institutions were reporting "low to no support" for the walkout.
The latest move is a further escalation of the unions' industrial action over a 1% pay rise offered to university staff. They insist the pay offer means that members have faced a 13% pay cut in real terms since October 2008.
Mike McCartney, Unite's national officer for education, said: "In the context of the cost of living crisis, the current 1% on offer is paltry."
A spokesman for the Universities and Colleges Employers Association (UCEA) said: "We are disappointed to see yet another strike day called with the intention to affect students' education."