A review by the University of Southampton showed that people taking antidepressants are at a higher risk of type 2 diabetes.
The study did not conclude whether the widely prescribed medications are responsible because some antidepressants lead to weight gain - a large driver of type 2 diabetes.
It called for more research into the link and for the medical profession to be alert to the danger.
Dr Katharine Barnard, a health psychologist from the university, said: "Antidepressants are used widely in the UK, with a significant increase in their use recently.
"Our research shows that when you take away all the classic risk factors of type 2 diabetes - weight gain, lifestyle etc - there is something about antidepressants that appears to be an independent risk factor.
"Heightened alertness to the possibility of diabetes in people taking antidepressants is necessary until further research is conducted."