E-CIGARETTES generate toxic chemicals similar to those found in tobacco and may harm the lungs and immune system, new research suggests.
The findings, from a study of mice, indicate that "vaping" is far from being a safe alternative to smoking tobacco.
In the experiments, mice exposed to e-cigarette fumes suffered mild damage to their lungs and became far more susceptible to respiratory infections.
Their immune responses to both viruses and bacteria were weakened by such an extent that some animals died.
Scientists also found that e-cigarette vapour contained "free radical" toxins similar to those found in cigarette smoke and air pollution.
Free radicals are highly reactive molecules that can damage DNA and cell membranes.
Professor Shyam Biswai, from Johns Hopkins University in the US, who led the research published in the online journal Public Library of Science ONE, said: "Our findings suggest that e-cigarettes are not neutral in terms of the effects on the lungs.
"We have observed that they increase the susceptibility to respiratory infections in the mouse models. This warrants further study in susceptible individuals, such as COPD (chronic obstructive pulmonary disorder) patients who have switched from cigarettes to e-cigarettes, or to new users of e-cigarettes who may have never used cigarettes."
For two weeks, mice were exposed to e-cigarette vapour in amounts equivalent to the doses inhaled by humans.
The animals were then infected with pneumonia bacteria or a strain of flu virus.
Compared with other non-exposed mice, they were much more likely to develop a weakened immune response.
Co-author Dr Thomas Sussan, also from Johns Hopkins, said: "E-cigarette vapour alone produced mild effects on the lungs, including inflammation and protein damage.
"However, when this exposure was followed by a bacterial or viral infection, the harmful effects of e-cigarette exposure became even more pronounced.
"The e-cigarette exposure inhibited the ability of mice to clear the bacteria from their lungs, and the viral infection led to increased weight loss and death, indicative of an impaired immune response."
The study is thought to be the first to investigate an animal's response to e-cigarette inhalation.
Why are you making commenting on The Herald only available to subscribers?
It should have been a safe space for informed debate, somewhere for readers to discuss issues around the biggest stories of the day, but all too often the below the line comments on most websites have become bogged down by off-topic discussions and abuse.
heraldscotland.com is tackling this problem by allowing only subscribers to comment.
We are doing this to improve the experience for our loyal readers and we believe it will reduce the ability of trolls and troublemakers, who occasionally find their way onto our site, to abuse our journalists and readers. We also hope it will help the comments section fulfil its promise as a part of Scotland's conversation with itself.
We are lucky at The Herald. We are read by an informed, educated readership who can add their knowledge and insights to our stories.
That is invaluable.
We are making the subscriber-only change to support our valued readers, who tell us they don't want the site cluttered up with irrelevant comments, untruths and abuse.
In the past, the journalist’s job was to collect and distribute information to the audience. Technology means that readers can shape a discussion. We look forward to hearing from you on heraldscotland.com
Comments & Moderation
Readers’ comments: You are personally liable for the content of any comments you upload to this website, so please act responsibly. We do not pre-moderate or monitor readers’ comments appearing on our websites, but we do post-moderate in response to complaints we receive or otherwise when a potential problem comes to our attention. You can make a complaint by using the ‘report this post’ link . We may then apply our discretion under the user terms to amend or delete comments.
Post moderation is undertaken full-time 9am-6pm on weekdays, and on a part-time basis outwith those hours.
Read the rules hereComments are closed on this article