• Text size      
  • Send this article to a friend
  • Print this article

Hopes for Ebola cure as tests on monkeys successful

HOPES of a breakthrough in the fight against Ebola have been raised by the 100 per cent successful treatment of monkeys with the deadly disease.

The experimental drug ZMapp cured the animals even when administered five days after infection.

All 18 rhesus macaques made a complete recovery, in contrast to three untreated monkeys that quickly fell seriously ill and died.

ZMapp is a blend of three laboratory-made antibodies designed to neutralise the virus. Two US doctors given the drug after they were infected with Ebola while in Liberia recovered, but it is not known whether they were saved by the drug or just lucky. About 45 per cent of those infected in the current outbreak have survived without treatment.

At least two other patients treated with ZMapp have died, possibly because help got to them too late.

The new research, published in a special report on Nature journal's website, provides hard evidence that the drug works.

A team of scientists led by Dr Gary Kobinger, from the Public Health Agency of Canada, wrote: "ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development. We hope initial safety testing in humans will be undertaken soon, preferably within the next few months, to enable the compassionate use of ZMapp as soon as possible."

The news follows a warning from the World Health Organisation that the Ebola outbreak in West Africa could eventually claim more than 20,000 victims.

Dr Alain Kohl, from the Medical Research Council/University of Glasgow Centre for Virus Research, said: "What needs to be done next is assess against how many strains and species of the virus it can act. Clinical trials in humans are not possible so some questions will go unanswered.

"At present too few people have received the drug to allow conclusions about efficacy and treatment timings, though in emergency situations it is at least one potentially useful option."

Contextual targeting label: 
Health

Commenting & Moderation

We moderate all comments on HeraldScotland on either a pre-moderated or post-moderated basis.
If you're a relatively new user then your comments will be reviewed before publication and if we know you well and trust you then your comments will be subject to moderation only if other users or the moderators believe you've broken the rules

Moderation is undertaken full-time 9am-6pm on weekdays, and on a part-time basis outwith those hours. Please be patient if your posts are not approved instantly.

258010