• Text size      
  • Send this article to a friend
  • Print this article

Scientists pioneer lab-grown red cells

RED blood cells grown in a laboratory are to be tested in patients for the first time by pioneering British scientists.

The first volunteers are expected to be treated by late 2016. If successful, the trial could pave the way to the wide-scale use of artificial blood derived from stem cells.

Blood cells freshly made in the laboratory are likely to have a longer life span than those taken from donors, which typically last no more than 120 days.

They would also be free from infectious agents such as viruses or the rogue prion proteins that cause Creuzfeldt-Jakob Disease (CJD). Professor Marc Turner, medical director at the Scottish National Blood Transfusion Service (SNBTS), who is leading the £5 million project at the University of Edinburgh, said: "Producing a cellular therapy which is of the scale, quality and safety required for human clinical trials is a very significant challenge. But if we can achieve success with this first-in-man clinical study it will be an important step forward to enable populations all over the world to benefit from blood transfusions.

"These developments will also provide information of value to other researchers working on the development of cellular therapies."

The pilot study will involve no more than about three patients, who may be healthy volunteers or individuals suffering from a red blood cell disorder such as thalassaemia. They will receive a small, five millilitre dose of laboratory-made blood to see how it behaves and survives in their bodies.

The blood cells will be created from ordinary donated skin cells called fibroblasts which are genetically reprogrammed into a stem cell-like state.

The resulting induced pluripotent stem (iPS) cells have the same ability as embryonic stem cells to develop into virtually any kind of body tissue.

Contextual targeting label: 
Education

Commenting & Moderation

We moderate all comments on HeraldScotland on either a pre-moderated or post-moderated basis.
If you're a relatively new user then your comments will be reviewed before publication and if we know you well and trust you then your comments will be subject to moderation only if other users or the moderators believe you've broken the rules

Moderation is undertaken full-time 9am-6pm on weekdays, and on a part-time basis outwith those hours. Please be patient if your posts are not approved instantly.

226652