The blueprint for how liquor is sold in the city has used detailed health data, crime statistics, the Scottish Index of Multiple Deprivation and the number of licensed premises to create eight areas which have reached saturation point.
Corner shops through to major pub chains and supermarkets bidding for a new alcohol licence will have to take on board the complex raft of statistics, sparking trade criticisms the city is "sending the message it is shut for business".
The new licensing policy also spells out to the NHS how to frame any objections to applications by using its own statistics.
Previous interventions by NHS Greater Glasgow and Clyde (NHSGGC) have floundered so badly it has been criticised for time-wasting by the licensing board.
Leading trade sources claim the policy creates "clear potential for greater NHS involvement" in the city's licensing system, while the lobbying group for 5000-plus pubs and brewers said the new approach risked driving away investment.
Patrick Browne, chief executive of the Scottish Beer and Pub Association, said: "Too often judgements about over-provision simply play a number game which ignores the fact that pubs and bars are increasingly selling more food and non-alcoholic items in a responsible environment.
"There's a danger Glasgow is sending the message that it's 'shut for business' which would be bad for the city in the longer term."
The Herald revealed yesterday how the new policy will give pubs within the city centre an extra hour, with the 1am curfew bringing Glasgow into line with Edinburgh and Aberdeen.
The plans are also to allow greater opening hours for nightclubs in outlying areas, extending outside drinking time, ending early opening for new applications and tightening up those bars with entertainment which can open until 3am.
The policy document said the cost of direct alcohol-related harm in Glasgow was £365 million in 2010/2011.