Mr Clegg said the research was needed to find out whether tenants could opt to take a smaller house or flat to avoid a deduction in their benefits.
Under the reforms, tenants with one spare bedroom have had a payment reduction of 14% and those deemed to have two or more spare have seen their benefits cut by 25%. For special cases, councils have been handed a discretionary housing fund to help tenants pay their rent.
But Labour claim that because there is such a shortage of smaller properties, many tenants cannot downsize and the fund is inadequate.
Labour deputy leader Harriet Harman said the shortage in social housing means only one in 25 households affected by the spare room subsidy can actually choose a smaller property without an extra bedroom.
Mr Clegg told the House of Commons today he suspected the problem varied across the country. He said a review was now under way to determine the impact of the Government policy.
He said: "Of course, I accept that there will be cases where for some households this change from one system to another creates real dilemmas which need to be addressed through the money we are making available to local authorities.
"To be honest, I have seen lots of widely different figures being cited about the impact of this policy - that is why we are commissioning independent research to exactly understand the impact of this.
"I suspect it varies enormously between one part of the country and another, and one local authority and another. That is why we are trebling, as I say, the resources we are making available to local authorities."
He added that the Government was now providing "hard cash for hard cases". He said: "I am not at all seeking to ignore that there are some individual cases which really do need the flexibility and the money from local authorities so that they can be dealt with."
Mr Clegg's comments came after a question from Ms Harman.
In her question to Mr Clegg in the Commons, she said: "What you don't want to admit, obviously, is that for 96% of tenants there isn't a smaller home to go to and so it is no wonder that the councils are saying that the discretionary housing fund on that basis is completely inadequate to help all the families who can't move and are falling into arrears.
"Will you recognise that this is a cruel and unfair policy that you shouldn't have voted for and will you repeal it now?"
Mr Clegg has not just faced pressure from Labour for supporting the policy. At the Liberal Democrat conference in Glasgow last month, many activists were angry at the party's support for the spare room subsidy and tabled a motion.
Activist Linda Jack, from Mid Bedfordshire, said she left the conference hall after the debate on the economy "wondering if there was still a place for me in this party".
Highlighting the policy, she added: "All I see is what appears to be an abandonment of our values."