In a speech to the Lib Dem conference, a year to the day before the crucial vote, the Deputy Prime Minister said that if Scotland voted to remain part of the UK, there must be a "new, cross-party approach" to further devolution.
He said told a packed conference hall in Glasgow that Home Rule, which would mean greater financial powers handed to the Scottish Parliament, was now a "tantalising prospect", adding that it was time for a "new settlement".
Mr Clegg said: "I unambiguously, unequivocally want Scotland to remain in the United Kingdom. The nationalists don't have a monopoly on passion in this debate. I love the way the UK is made up of different peoples, different traditions, different histories.
"I've sat in rugby grounds shouting my head off for England while the Scottish fans have shouted back just as loud, and it is a very special thing when good natured rivalry can flourish side-by-side with a feeling of affinity and closeness that comes from being a family of nations. And on every single level we are stronger together than we are apart."
He added: "A Scottish decision to remain within the UK family can and must give way to a new settlement for this nation. The Liberal Democrats have always fought for more powers for Scotland - and Wales and Northern Ireland too. In coalition we have overseen the biggest transfer of financial freedoms in 300 years. And, from Gladstone to Grimond to today, we continue to believe in Home Rule.
"Our vision is of a proud and strong Scotland, within the United Kingdom, in charge of its own fate but part of a family of nations too. This is a vision shared by many Scots and, increasingly, the other major political parties.
"That is why, once the issue of Scotland's continued participation in the United Kingdom is hopefully settled next year, I want to see a new cross-party approach to the next advance in Scottish devolution.
"Delivering Home Rule is a tantalising prospect that is now closer than it has been for a generation, so let's get out there to win the referendum in favour of keeping our nations together and then work with others to deliver the future Scotland wants."