His agent said the veteran satire comic died peacefully with his wife Emma at his bedside.
Vivienne Clore said: "It is with great sadness that I write of the death of John Fortune this morning aged 74.
"He died peacefully with his wife, Emma and dog Grizelle, at his bedside.
"A renowned satirist, early work included contributions to Peter Cook's Establishment club and more latterly his work with long term collaborator, John Bird and Rory Bremner.
"He is survived by his adored wife, Emma and three children."