The actor allegedly told the girl, "It's Okay, just keep calm, stay asleep... I'm going to get rid of the evil," as he sexually abused the youngster, Manchester Crown Court heard.
Le Vell, 48, who plays car mechanic Kevin Webster in the ITV soap, is facing 12 charges in all - five counts of rape, three of indecent assault, two counts of sexual activity with a child and two of causing a child to engage in sexual activity.
Le Vell, who is on trial under his real name of Michael Turner, denies the offences and shook his head saying "not guilty" in a strong voice as the charges were put to him before his trial began.
After 12 jurors were selected, two members asked to be excused and two replacements were selected for a jury of eight women and four men.
Judge Michael Henshell warned them: "The man on trial is Michael Turner, not the character he plays."
Eleanor Laws QC, prosecuting, then began the opening address, telling the jury Le Vell was a "heavy drinker".
She said: "There is no room in your deliberations for any form of emotion or sympathy or prejudice.
"You must judge the facts of this case using your own common sense."
Ms Laws said the abuse began when Le Vell slipped his hand under the girl's clothing.
Afterwards Le Vell seemed happy, "as if it was giving him pleasure", the jury heard.
The abuse progressed to Le Vell allegedly forcing the girl to touch him, with her "too frightened" to do anything, the court heard.
"Interlocking her hands in his, he took control of her hand and put it down his underwear," Ms Laws told the court.
The first time he raped the girl, she clutched one teddy bear while Le Vell put another teddy bear over her mouth, it is alleged.
"It's okay. I'm making the evil stop once and for all now. It'll be fine," he allegedly told the girl.
He then raped the youngster, kissed her on the cheek and left, the court heard.
The jury heard that on another occasion Le Vell raped the girl orally.
"He did not say anything this time, and after he had finished, he just got up and left," Ms Laws said.
"She recalls that afterwards she felt sick," the prosecutor added.
The actor, who was with his legal team and a minder, said "Good morning" to the media as he arrived at court.
Le Vell, who lives in Hale, Cheshire, is one of TV's most famous faces after playing Kevin Webster for the past 30 years.
Originally from Manchester, he began his showbusiness career at the Oldham Theatre Workshop after taking an interest in amateur dramatics while at school.
He first joined Coronation Street in 1983 and quickly endeared himself to fans, who have followed the trials and tribulations of Kevin, from Brian Tilsley's apprentice mechanic through to his stormy marriage to Sally, played by Sally Dynevor, and fathering two girls, Rosie and Sophie.
ITV has said he will not be appearing in any further episodes of the soap pending the outcome of legal proceedings.
His trial before Judge Michael Henshell is scheduled to last around two weeks.
Meanwhile, fellow Coronation Street star William Roache has pleaded not guilty to committing historic sexual offences against five girls.
The 81-year-old actor, who plays Ken Barlow in the soap, formally denied the charges in a hearing at Preston Crown Court.
The veteran soap star was arrested at his home in Wilmslow, Cheshire, in May and charged with two counts of raping a 15-year-old girl in East Lancashire in 1967.
He was later additionally charged with five indecent assaults involving four girls aged between 11 or 12 and 16, allegedly committed in the Manchester area between 1965 and 1968.
Roache entered the dock and confirmed his name to the clerk.
The indictment containing the seven counts was then read out to him and on each allegation he responded with a firm, clear answer of "not guilty".
Roache's trial will begin at Preston Crown Court on January 14 and is scheduled to last four weeks.
He remains on bail with various conditions including residence, no direct unsupervised contact with anyone under 16 and not to approach named witnesses.
When he was initially charged, Roache said he was "astounded and deeply horrified" by the accusations and vowed to "strenuously deny" the allegations.
The world's longest-serving soap actor, he has played Ken Barlow in the ITV1 soap since its launch but will not be appearing in the programme until legal proceedings are concluded.
Roache made no comment to the media as he left the building following the 30-minute hearing in front of the Recorder of Preston, Judge Anthony Russell QC.