Neuroblastoma most commonly occurs in either one of the two adrenal glands, situated in the abdomen (tummy) and in nerve tissue that runs alongside the spinal cord, in the neck, chest, abdomen or pelvis.
Neuroblastoma can spread to tissues beyond the original site such as the bone marrow, bone, lymph nodes, liver and skin.
As with most cancers, the cause of neuroblastoma is unknown. It is not infectious and cannot be passed to other people.
Stage 4 neuroblastoma means it has spread to distant lymph nodes, bone, bone marrow, the liver, the skin or other organs.
The first symptoms are vague, such as tiredness, loss of appetite and pain in the bones.
Fewer than 100 children in the UK are diagnosed each year with neuroblastoma. Most children who get this cancer are younger than five years old.
It is the second most common solid tumour in childhood, and it makes up 8% of the total number of children's cancers.