Donald Shaw, the artistic director of the festival, which runs from January 16 to February 2, said the events would be called If The Song Changes.
They will feature musicians from Scotland, Ireland, Norway, Quebec and Catalonia who will discuss the poll and its implications for Scotland's culture.
Shaw, who is in favour of Scottish independence, said he thought it was right the festival should address the poll without officially having a political position.
Mr Shaw said: "It will not be a pro or anti-event at all."
The festival unveiled its new programme yesterday, which will include concerts at the new SSE Hydro venue in Glasgow, performances by Del Amitri, Imelda May, Capercaillie, Bobby Womack, Bill Callahan and Julie Fowlis and Mogwai.