The multi-award-winning band will tour the US before heading to the UK in September.
The current line-up includes Mick Fleetwood and John McVie – both original members since 1967 – as well as Lindsey Buckingham and Stevie Nicks, who joined the band in 1975.
The tour also marks the 35th anniversary of the release of their Rumours album, one of the most successful albums in recorded history, with sales exceeding 40 million.
Mick Fleetwood said: "Having started Fleetwood Mac with John McVie in 1967, it has always been so gratifying that, despite the various incarnations, the band has survived.
"Throughout the years, though, the one thing that has remained constant is our fans. I am looking forward to getting back behind the drum kit, reconnecting with the fans and sharing the stage with my fellow band members."
He added: "I'm really looking forward to hitting the road with Stevie, Lindsey and John in 2013. It's been over three years since we've toured together [when they played Glasgow's SECC] and happily the break allowed me to explore a lot of uncharted territory as well as experience tremendous growth creatively. I'm excited to bring that back to the band."
The band also had huge hit albums with Tusk in 1979 and Tango in the Night in 1987.
Tickets will go on sale at 9am this Friday.