The two men and two women were arrested and detained in custody in connection with an alleged breach of the peace after halting the weapons transporters in Glen Fruin, near the Clyde Submarine Base at Faslane, after 1am yesterday.
Scottish CND and Nukewatch said they had followed a convoy of around 20 vehicles, including four they believe were equipped to carry Trident missiles, through new M74 extension across Glasgow's south side and along the A82 to Glen Fruin.
The convoy had made its way from the Atomic Weapons Establishment at Burghfield on Thursday morning and arrived at the Coulport facility near Faslane at 2.30am on Friday.
Scottish CND co-ordinator John Ainslie, who tailed the convoy, said: "This is an insult to the people of Glasgow and the rest of Scotland.
"The convoy was probably carrying six Trident bombs, each one seven times more powerful than the bomb which destroyed Hiroshima in 1945."
A police spokeswoman said: "Two women aged 29, a man aged 23 and a man aged 32 were arrested and detained in custody and will appear at Dumbarton Sheriff Court on Monday after an alleged breach of the peace involving a military convoy on the A817."
The A817 is the so-called Glen Fruin Haul Road, a purpose-belt highway linking the A82 at Loch Lomond across Glen Fruin with Coulport on Loch Long and Faslane on Gareloch.