There were no reported injuries in the accident on the A90 at Kinfauns in Perth and Kinross but it caused long tailbacks.
Black ice was believed to have caused accidents on the M90 at Kinross and the A94 at Perth aerodrome, where a car had overturned.
Police in Dumfries and Galloway issued warnings to motorists urging them not to travel on the M74 motorway, the A75 between Dumfries and Annan and all minor roads due to completely treacherous conditions.
Sergeant Robin Ferguson, from Dumfries and Galloway Police, said: "Road conditions on the M74 motorway are completely treacherous. The general advice at the moment is avoid travelling on that road. North-bound it is completely blocked due to a jack-knifed lorry. Visibility is very poor as the snow continues to fall.
"The A75 between Dumfries and Annan also has a warning of not to travel on the road. There are a number of LGVs stuck in that area and tailbacks are about four or five miles long with congestion in the east of the region at a standstill.
"All minor roads have not been treated and we would advise people not to travel on them. The rest of the A75 and other A-class routes are passable with care."
He said there was travel disruption on the A701 due to two minor injury road traffic collisions.