The £9 million development will see an extensive refurbishment of the National Sports Centre Inverclyde in Largs, North Ayrshire, Sport Secretary Shona Robison announced.
The para-sports hub - described as the first of its kind in the UK -will allow disabled athletes to train at "outstanding" fully integrated facilities in a wide range of sports.
It comes after Glasgow 2014 featured the highest number of para-sport medal events in the history of the Games, with Scottish athletes winning seven medals.
The Scottish Government will invest £6m towards the refurbishment, which will also provide 60 fully adapted residential rooms.
The remaining £3m will come from sportscotland.