Edinburgh judo sisters Kimberley and Louise Renicks both won gold and there was joy in the pool at Tollcross where Hannah Miley, from the north-east, made it three top-place finishes after triumphing in the 400m individual medley.
Scots Ross Murdoch and Michael Jamieson fought out an enthralling clash in the 200m breaststroke, with the Stirling swimmer edging out the local boy - just as he did earlier in the day in the heats, to notch gold and silver.
Keen-eyed TV viewers noted from a distance how Murdoch reacted to the victory, apparently saying: F**k me!"
Kimberley Renicks took gold in the under-48kgs final with victory over India's Sushila Likmabam at the SECC. Sister Louise Renicks won gold in judo's -52kg class.
Louise Martin, chairwoman of sportscotland, said: "What an amazing achievement for Kimberley Renicks. We're all absolutely delighted that she will go down in history for being the first Scot to win gold at the Glasgow Games.
"It has been a terrific start for Team Scotland and our vocal, home crowd can help inspire the team to a record medal haul."
Scotland had already tasted success at the Sir Chris Hoy Velodrome with para-cyclists Aileen McGlynn and Louise Haston claiming silver.
Mike Whittingham, director of high performance at the sportscotland institute of sport, said: "I am delighted that Aileen McGlynn and Louise Haston have secured Team Scotland's first medals at these Games. It is an excellent start to what promises to be the best ever Games for Team Scotland.
"I am also very proud that Louise came through sportscotland's Gold4Glasgow programme, aimed at identifying individuals with the talent and commitment to represent Scotland in Glasgow. Our faith has been justified and Aileen and Louise have done Scotland proud by winning silver."
Scot Stephanie Inglis claimed silver in the women's under-57kgs, losing to England's Nekoda Davis.
Scotland judo fans were also on their feet as veteran John Buchanan won bronze. The 39-year-old Edinburgh Sportif Judo coach came out of a decade-long retirement to fight in Glasgow, and his endeavour was rewarded as he defeated beaten semi-finalist Daniel Le Grange of South Africa with an ippon score, given on video review - and promptly did a full back-flip on the tatami mat in celebration.
There was more home success for Scotland as Glasgow fighter Connie Ramsay, a defeated quarter-finalist earlier on Thursday, secured bronze when she pinned down Cameroon fighter Paule Sitcheping.
Scotland collected another bronze medal when James Millar - a late call-up for Scotland as replacement for the injured 100kg judoka James Austin - defeated Mathews Bpunza of Zambia with a late ippon throw.
First Minister Alex Salmond has saluted the Scottish medallists who have kick started Team Scotland's Commonwealth Games.
Congratulating all Team Scotland medal winners on the first day of the Games, Mr Salmond said:
"This has been a great day for the Games, with big crowds, excellent performances and truly memorable displays of Glaswegian hospitality.
"I'd like to also extend my congratulations to Team England who currently lead the medal table with six Golds.
"Many congratulations to everyone who took home a medal today. Each athlete displayed incredible physical prowess and depths of mental fortitude. Watching the finals you could see the clear determination in each of our winners. These medal wins will hopefully be followed by many more for Team Scotland."