Handbag Heaven in Edinburgh's Howe Street was broke into between 5.15pm on Saturday and 10am on Monday.
The items stolen include a cream, leather Hermes vintage classic 1954 handbag with gold clasp and a Jimmy Choo perforated, tan, leather bag with double gold bangle.
Also taken were a monogrammed Louis Vuitton large hobo bag in brown suede and a Prada tan and python leather bag with a clip top and rope handles, sunglasses, jewellery and belts.
The goods are believed to worth a five-figure sum in total, police said.
Constable Gavin Howat said: "All of the items taken from the store are extremely expensive and those responsible may attempt to sell them on at a discounted rate. As such, anyone who is offered any handbags matching the description of these is asked to contact police immediately.
"Similarly, anyone who remembers seeing anything suspicious in the Howe Street area over the weekend or early on Monday morning is also asked to come forward."
Anyone with information can call Police Scotland on 101 or Crimestoppers anonymously on 0800 555 111.