Mrs Marwick will meet up with some of the residents of Shieldinch - the fictional community where the BBC Scotland drama is set - as well as members of the crew.
She said it would be "fascinating to see behind the scenes" of the show, which is filmed in Dumbarton.
In addition Mrs Marwick will also use the visit on February 24 to find out how the River City studio, which employs about 200 people, has boosted the local economy.
The event is part of Holyrood's Parliament Day programme, which takes key figures from the Scottish Parliament out of Edinburgh to towns across Scotland.
She will be joined by Dumbarton MSP Jackie Baillie, with the two to tour behind the scenes to find out about the editing process.
The Presiding Officer will also meet staff and customers at Cafe Connect, a not-for-profit social enterprise run by West Dunbartonshire Council that employs adults with learning disabilities.
Mrs Marwick will also record news stories for the Rockvale Rebound talking newspaper, which is delivered to the visually impaired.
She said: "I am delighted we'll be visiting Dumbarton and I am very much looking forward to meeting local residents."