This time of year will "never be as it should", the parents of missing Madeleine McCann have said as they prepare for a sixth Christmas without their daughter.

Kate and Gerry McCann said the eldest child's absence is acutely felt by the family, including by younger siblings Sean and Amelie, with the words "If only Madeleine was here too" regularly spoken.

In a Christmas message written on the Find Madeleine website, Mrs McCann thanked people for their support and said they remained hopeful the Portuguese authorities would reopen the case.

Madeleine was nearly four when she vanished from her family's holiday apartment in Praia da Luz in the Algarve on May 3, 2007, as her parents dined at a tapas restaurant nearby.

The McCanns have campaigned tirelessly for information about their daughter's whereabouts, battling for a review by the Metropolitan Police, which has now been under way for more than 18 months.

Mrs McCann wrote: "As we approach the end of another year, we'd like to thank everyone again for their amazing support.

"It is both heart-warming and reassuring to know that after all this time Madeleine still remains in so many people's hearts and minds. This solidarity and commitment gives us great hope."