The pyrolysis plant, at Carnbroe, North Lanarkshire, is almost certain to be built by award-winning butcher Simon Howie's firm Shore Energy after the local council lost an appeal against a decision to grant planning permission at the Court of Session.
The plant, which will burn 160,000 tonnes of rubbish and turn it into energy, had been rejected by the council and then approved after an appeal to the Scottish Government.
Now locals have called for ministers to get involved again. Gerald Somers, chairman of Monklands Residents Against Pyrolysis Plant, said: "To say I'm disappointed would be an understatement. It should never have gone this far and I feel that ministers have shirked their responsibility. They have ignored local democracy as North Lanarkshire Council is against this plant, as are more than 5000 people."
Campaigner Maggie Proctor said: "We are disappointed but it does not alter our clear course of action. Our campaign will continue. The Scottish Government has the chance to call this project in and stop it.
"The plant is not needed, it's not wanted and this is not the right way to deal with landfill."
Shore Energy managing director Mr Howie has called for the community to get behind the project, which he says will create jobs. He said: "We look forward to demonstrating that the extra processing capacity of this facility will deliver real choice as well as a competitive landscape for councils and commercial operators which will help keep the costs down for local taxpayers."
A Scottish Government spokeswoman said: "Scottish ministers note the decision of the court."