The £11 million Premier Inn will open ahead of schedule in June at Pacific Quay, Glasgow.
The jobs, including four apprenticeships, range from receptionists and restaurant workers to housekeeping and maintenance staff.
Barry Halfpenny, Premier Inn Glasgow city cluster general manager, said: "Opening in time for the Games has been our aim since plans were first approved for the site, which everyone involved in the project has worked tirelessly to make happen.
"The hotel is in a fantastic location with incredible views both of the city and along the river, which we are confident not only business and leisure travellers will be impressed with but locals too."
The 180-bedroom hotel and restaurant is located on a three-acre site next to the BBC and STV headquarters and opposite the Hydro Arena and SECC.