This year's must-haves range from a doll named Cayla who uses speech-to-text Google software to look up answers to questions online, to the Doh Vinci 3D Deluxe Styler which mimics the principles of 3D printing, the famous London store said.
The £75 My Friend Cayla can answer questions ranging from her likes and dislikes to general knowledge and sports results, thankfully only after she has been synced with a smartphone or tablet.
Cayla, who is suitable for children aged four and over, comes complete with "lovely hair and a cool outfit", while Google's SafeSearch technology means there will be no experimenting with "bad words" and unsuitable content.
The £25 Doh Vinci Style and Store Vanity allows children to become a 3D designer, while the latest Kiddizoom Smart Watch comes with a colour touch screen and motion sensor, can take photos and edit them, record videos and play three built-in games, all for £50.
Even Barbie is embracing "state-of-the-art technology" with the £40 Colour Change Bag which allows youngsters to hold it against any item of clothing and press a button to match more than 100 different shades.
For those with slightly less sophisticated interests, the Teksta T-Rex walks backwards and forwards, moving his head from side to side, while sniffing and chewing on his favourite bone, and spits it out with a "giant burp" when he has had enough.
The most expensive toy on the list is the £135 Leapfrog LeapTV, a gaming system for three to eight-year-olds that features Wi-Fi and a camera which captures movement "for perfect pre-school gaming and activities" covering reading and writing, mathematics, science and social studies.
The £115 Transformers Chomp and Stomp Grimlock is a 20in robot with a mighty sword to take on enemies, and the £65 BoomCo Rapid Madness blaster features single-shot for accuracy or 20 darts in seconds that fire up to 50ft.
Young fans of the Disney film Frozen can look forward to Ice Skating Anna and Ice Skating Elsa dolls, while the £100 Xeno is a "cute monster" that interacts with a dedicated app to "encourage hours of play" using eight touch sensors and audio inputs.
Hamleys said: "This Christmas, toys will become truly 21st century and for the first time positively reflect the amazing world we live in.
"They range from Cayla, the doll that uses speech-to-text technology to look up answers to questions online, to the state-of-the-art Barbie Colour Change Bag which enables it to literally blend with any outfit the child is wearing.
"There is also the Doh Vinci 3D Deluxe Styler that mimics the principles of 3D printing to inspire children's creativity.
"This year's top 10 will surpass even the most savvy child's expectations."