Crews were called to a fire at a two-storey house in Glasgow`s Sumburgh Street at 6am where an occupant was found dead.
Strathclyde Fire & Rescue said the blaze broke out in the ground floor kitchen area. An investigation into the cause is under way.
A spokesman said: "This incident is a stark reminder of fire being a threat to every community in the west of Scotland."
"We need to accept that fire can strike anywhere and take action to protect ourselves, our families, friends and neighbours.
"It is absolutely vital that every home has a working smoke alarm on each level of the property, which will allow residents time to escape if a fire does break out."
Officers did not release any details of the householder who died.
More than 30 firefighters had earlier tackled a blaze at a derelict primary school in the city.
Crews dealt with billowing smoke and flames which engulfed Westercommon primary in the Ruchill area at around 3am.
Incident commander Eddie Mullen, from Strathclyde Fire & Rescue, said: "The crews were faced with a well developed fire from the outset and they worked tirelessly in difficult conditions to prevent the spread of fire to other parts of the building and the neighbouring properties.
"The fire was quickly contained and is now under control however crews will be on the scene for a considerable time."
Scottish Power attended the scene due to nearby power lines but they were not affected by the fire, the rescue service said.