The 19-year-old was a passenger on an off-road bike when the incident occurred in Larkhall, South Lanarkshire, yesterday evening.
The motorcycle was being ridden by a 17-year-old man when it collided with a Honda Civic at around 6.35pm, Police Scotland said.
The passenger struck the road and was pronounced dead at the scene in Craigbank Street .
The rider was taken to Wishaw General Hospital and treated for a serious hand injury.
The 37-year-old male car driver was not injured but has been left "very upset".
Police are appealing for anyone with information about the incident to contact them on 01698 483045.