She and Coleen Nolan are to rejoin the panel of the daytime show six years after she left. Nolan - whose sister Bernie died after a battle with cancer earlier this year - will return as a panellist after leaving the programme in 2011.
A BBC Scotland spokesman said Adams would continue to present her morning radio show Call Kaye as normal until Christmas and then next year will continue it on only one day a week - Friday. Details of her replacement from Monday to Thursday will be announced in due course.
Adams said: "I've thoroughly enjoyed the last three years on Call Kaye. I've been in the unique position to hear the opinions of real people from across Scotland. I'm delighted that I'll be able to continue with the weekly programme on Radio Scotland, alongside my other commitments."
She was one of the original presenters when Loose Women launched in 1999 and will come back to join Carol Vorderman and Andrea McLean as anchors of the hour-long weekday show in which the presenters discuss issues of the day and chat to guests.
Adams added: "I felt privileged to have been one of the original Loose Women and now feel doubly privileged to be invited back six years on.
"Loose Women is perhaps the only show on which you can be unapologetically female - smart, sassy, sometimes stroppy, sometimes silly but always straight- talking. It's the world and what matters in it through a female prism, a perspective we don't see or hear enough of, and I can't wait to play my part again."
Nolan, who marks her return on Monday, said: "After two and half years away, now feels like the right time to come home to Loose Women.
She added: "It's the public that have always mattered the most to me and the Loose Women audience are the most loyal of all.
"They have been so supportive to my family during the devastating loss of our beautiful sister."
Helen Warner, ITV's director of daytime, said she was thrilled to welcome the pair back.
She added: "They both played such a vital role in making the show a success and have been much missed by the other panelists and viewers alike."