Tukwini Mandela will be the guest of honour at a ribbon-tying ceremony in the city's Nelson Mandela Place, hosted by Action for South Africa (Actsa) Scotland.
Officials and guests will tie ribbons in the colours of the South African flag to the railings of St George's Tron Church at 1.30pm to mark the first Mandela Day since the former leader's death in December.
Brian Filling, Actsa Scotland chairman and Honorary Consul for South Africa, said: "Glasgow was the first city in the world to honour Mr Mandela with the Freedom of the City.
"It is fitting - just seven months after millions around the world mourned his death - that we reflect on and celebrate his life and legacy in the Glasgow street that bears his name.
"We are delighted that Tukwini Mandela can be with us in Glasgow on Mandela Day, her grandfather's day.
"Mandela Day is about celebrating the life of Nelson Mandela and the values for which he stood and struggled all of his life. He fought the institutional racism of apartheid for which he was imprisoned for 27 years.
"The unity and equality of people of all races will be the thread that ties together everything we will do during Mandela Day Scotland 2014."
Mr Filling added that Actsa Scotland was asking people to dedicate 67 minutes of their life to humanitarian voluntary work to mark the 67 years of public service Mr Mandela gave.
The group is also asking supporters to help sort out and donate children's books to be sent to South Africa as part of a book appeal.