Alex Salmond will visit Hawick, 15 miles from the English border, on the latest leg of the Scottish Government's public meetings around Scotland.
Government ministers visited Shetland last month where Mr Salmond pledged to examine decentralisation of power to the islands and predicted that Scotland would remain a member of "five unions" if it secures political independence from the United Kingdom.
He is expected to continue his theme of keeping the Union of the Crowns, the European Union, Nato, the pound and the "social union" while severing ties with Westminster in his speech to Hawick residents.
"This year we are taking the cabinet to the four corners of Scotland and although the first event location, Shetland, was about as far from Hawick as it is possible to get in Scotland, people's priorities remain the same, and I expect the same level of engagement from Borders' folk on issues such as jobs, healthcare, law and order and agriculture," Mr Salmond said before the visit.
"I hope to see as many people as possible at our public discussion event at Hawick High School. Unsurprisingly, the opportunity to buttonhole ministers on a range of issues has proved extremely popular at past events and I am looking forward to another stimulating discussion with the people of Hawick."
Ministers visited nearby Melrose during their first summer tour in 2007 and since then the Scottish cabinet has also taken in Dundee, Stornoway, Aberdeen, Glasgow, Dumfries, Inverness, Pitlochry, Isle of Bute, Dornoch, Stirling, Kilmarnock, Stranraer, Elgin, Kirkcaldy, Skye, Orkney and Renfrew.
This year's programme will also see events in Campbeltown and Fraserburgh.
Mr Salmond said: "I am absolutely delighted to be bringing the cabinet back to the Borders four years after we first visited the community as part of our summer cabinet programme.
"The event at Melrose was extremely successful, and I hope that this year's visit to Hawick can emulate that success by taking cabinet directly to the people and ensuring they get a chance to discuss the issues they care about directly with my team of ministers."