New figures show NHS Ayrshire and Arran had 483 A&E attendances for children aged 17 and under with an alcohol-related condition in 2012/13, more than any other hospital area in Britain.
The statistics were revealed as part of a probe into the number of young teenagers being treated for alcohol-related conditions across the UK.
The figures show there were 30 cases of children of primary school age or under staying overnight in hospital with an alcohol-related illness during the same period.
Girls in the 12 to 14 and 15 to 17 age groups outnumbered boys for attendances at A&E for alcohol-related conditions in 2012/13, while boys outnumbered girls in the category of age 11 and under.
Staff at NHS Ayrshire and Arran have spoken of the dangers faced by underage drinkers and say there are particular difficulties in dealing with them as many are too intoxicated to take care of themselves.
Morten Draegebo, an A&E consultant at Crosshouse Hospital in Kilmarnock, said: "The typical patient may be found in a field. They often need to hide away from any sort of adults in the area so they're picked up by the ambulance service.
"They have difficulty locating where they are because the description comes through from a distressed half-drunk teenager potentially saying they're under a tree somewhere in a large park."
Dr Draegebo added: "We have had many cases where young teenage females have come in saying that they may have been sexually assaulted and they're that intoxicated and are distressed and say, 'I may have been', but they don't even know if they have been or not."
Overall, the number of attendances at A&E for under-18s with alcohol-related conditions fell from 7821 in 2011/12 to 6580 in 2012/13, according to the responses to a Freedom of Information request by BBC Radio 5 Live's Victoria Derbyshire programme to NHS Trusts and health boards.
Dr Evelyn Gillan, chief executive of Alcohol Focus, Scotland said the figures raised serious concerns.
She said: "Children are especially vulnerable to the damaging effects of alcohol and drinking at such a young age can have immediate negative effects as well as increasing the risk of problem drinking later in life.
"Alcohol companies are increasingly talking to young people through social media, an area of alcohol marketing that is virtually unregulated."
Public health minister Michael Matheson said: "We need to protect young people from the harm caused by alcohol misuse and to support them to make positive choices.
"That is why we have worked to strengthen legislation to crack down on those who sell alcohol to under-18s, improve education in schools and have published guidance for parents and carers to talk about alcohol and highlight the importance of the example they are setting to our young people."