Going head-to-head over the tiles today at the Cavendish Conference Centre in London will be Allan Simmons from Coldingham in the Scottish Borders and Aberdonian Paul Allan.
To most people the classic game is traditionally played around the table, usually over the festive period. But for the hardcore Scrabble pros there are dozens of dedicated clubs around the country which hold competitive matches on a regular basis.
Plans are even being made to hold an international tournament to coincide with next year's Commonwealth Games in Glasgow.
Much like in chess, the most expert players are known as grandmasters and there is a clock to time the game. Competitors have 25 minutes in which to complete all their moves, but can choose to use it how they want - for example, take 30 seconds to complete one word but 10 minutes to complete another.
A definitive list of words has also been drawn up to ensure no arguments break out when, for example, aa is played - which Scrabble aficionados will, of course, know is valid and means rough, cindery lava.
Simmons, 56, who has been playing since the mid-1970s and won the National Scrabble Championship in 2008, has been limbering up for today's final by going through lists of words to keep them in his memory.
"I don't prepare by playing," he said. "I am going through the top 5000 eight-letter words. Most of them I probably know anyway, but you have got to have confidence you know the word."
Simmons, who is involved in drawing up the official word list for the game, said it included some obscure words - such as prys, an obsolete spelling of prise that dates back to Shakespeare.
"There is an issue now as all the players have learned the words off by heart, but there is a lot of baggage in there of obsolete words which could really disappear to make room for new, trendy words coming in," he said.
"We update it every five years or so, but we never get rid of anything really.
"There is a debate, with a school of thought that says those words are bad for the game's image, as people say they are not really words."
Allan, 43, who is a mathematics and science teacher and previously won the national title in 2007, has been revising around 2000 words every day in preparation for the final. But he pointed out that it was a common misconception that Scrabble is a game just about language.
"For most of the top players their work or background is very much from the analytical, mathematical side," he said. "You have got accountants, programmers and physicists, for example.
"I would say 80-90% are very interested in words but some aren't at all. For myself, the appeal of the game is with my work and studies being on the mathematical and physics side and more analytical.
"It combines that side of the brain with the language side - and there is nothing which combines them quite like Scrabble does," he said.
There are around 40 Scrabble clubs across Scotland, with a dedicated organisation north of the Border affiliated to the Association of British Scrabble Players (ABSP).
Amy Byrne, 62, chair of the Scottish Scrabble Association, said it was regretful that while schools often encouraged chess clubs, they did not set up Scrabble clubs.
"Words are a tool - so the better your vocabulary, the more chance you have of getting out of sticky situations (in the game)," she said.
"In Asia, in countries like Thailand, children are taught Scrabble in schools as a way of helping them to learn English.
"Some of the top players in the world are Thai and Malaysian," she added.
Byrne said they were currently seeking sponsors to run a "Commonwealth Games" tournament, which was planned to coincide with the end of the actual Games and have teams of international competitors playing in Glasgow.
Today's final in London of Simmons v Allan will be decided on the best of five games.
The players will compete in a room on their own, but every move will be broadcast live to a nearby room with an audience of up to 100 people watching on and a commentator providing a running analysis of the battle.
With prize money of £2500 at stake, the match will also be overseen by an official adjudicator.
Despite its strict rules and straightlaced appearance, scandal has still rocked the world of Scrabble on occasion over the years.
Last year, one of the top young Scrabble players in the US was kicked out a championship in Florida after being caught hiding blank letter tiles - which can be used as wild cards - by dropping them on the floor.
And in 2004, an American competitor caused uproar during a US Scrabble contest finals when he combined E, L and Z into LEZ for a 32-point score.
Although the slang term for a lesbian would have been legitimate under normal Scrabble rules, a list of potentially offensive words had been banned for the finals, which were being televised.
Meanwhile, the game ditched any staid reputation in 2010 when transsexual Mikki Nicholson was crowned the UK national champion in a pink wig and matching PVC dress.