You can take the cable car as it climbs Nob Hill or wander around Fisherman's Wharf on foot. You could even take the ferry to Alcatraz.
But it's more than likely you won't wheely your bike down the city's hills, balance on a narrow metal fence above a steep drop or bump and bounce over the city's monuments. Not unless you're Danny MacAskill, anyway.
The Scottish stunt rider has been filmed doing just that for a video during which he is seen cycling through the city's historic districts and using them as a venue for his daredevil escapades.
In the video, he is seen climbing walls, sculptures and even bouncing into trees on his custom-built bicycle.
"I always feel like I've had a different way to view a city," the 26-year-old, who lives on Skye, reveals in the video.
"When I'm looking around the streets, you can visualise how you'd ride different features.
"It's just kind of a natural thing you'd have in your head. You're kind of looking around seeing how you can jump on that rail and then maybe jump to this wall."
MacAskill, who has been named one of 2012's adventurers of the year by National Geographic, became world-famous via YouTube after he put a video of himself bouncing around Edinburgh on his bike back in March 2009.
His 2011 short film Industrial Revolutions, which saw him leaping between train cars and traversing two-inch beams 15ft above concrete, generated three million views on YouTube in a month.
Cycling along a narrow fence unsurprisingly requires more than a little concentration, he explains in his latest video sponsored by Remington.
He said: "You have to focus 100% and really put everything into it. You think you're going to come off at any second, but somehow you manage to piece it all together and make it to the end."
Alternatively, you could always call a cab.