The 62-year-old man died at the scene after his vehicle was involved in a collision with a four-wheel drive vheicle on the A83 at Kennacraig, about five miles south of Tarbert, on the Kintyre Peninsula in Argyll and Bute.
The crash at 7.10am yesterday caused the main route between Campbeltown and Tarbert to be shut for most of the day, leading to widespread disruption. Ferry services were also hit, with Kennacraig ferry terminal being the main route from the area to Islay.
The incident involved a southbound Mitsubishi 4x4 and the northbound minibus.
The 21-year-old driver of the Mitsubishi was taken to Campbeltown Hospital, but was released after treatment for minor injuries.
Police last night said there were 10 male passengers on the bus at the time of the crash, although their ages have not been released. Some of them are thought to have suffered serious injuries.
Six of them were taken by ambulance to Mid Argyll Hospital in Lochgilphead.
However, one of the injured was subsequently transferred to the Southern General Hospital in Glasgow.
Another passenger has since been taken to the Royal Alexandra Hospital in Paisley.
Four of the bus passengers were taken to Campbeltown Hospital, where they are currently receiving treatment.
The A83 was closed for specialist crash investigators to carry out enquiries at the scene. The road was reopened in both directions by around 5pm.
Police have appealed for any witnesses to the crash, or anyone with any further information, to come forward.
The details of the deceased man will not be released until relatives have been informed.
The crash caused disruption to CalMac ferry crossings.
The 6pm ferry from Kennacraig was cancelled.
Meanwhile, the 6pm ferry from Islay was delayed until 7.30pm and departed from Port Askaig.
Following the diversions, the 7am sailing today from Islay will depart from Port Askaig, rather than Port Ellen.
There will be an additional sailing at 8am from Port Ellen today.
Meanwhile, two women and one man have been taken to hospital after a crash involving two cars.
Emergency services were called to the B7020 at Charlesfield Farm near Annan in Dumfries and Galloway at around 5pm, said police.
The incident involved a white Renault Megane and a grey Peugeot 208.
The three casualties were taken by ambulance to the Dumfries and Galloway Royal Infirmary with minor injuries.