The university plans to tell the story of the war's impact on Scottish people who worked in industry or education during the turbulent era through a series of events over four years.
It will particularly focus on the 4506 members of the Glasgow University community who served in the war, and the 761 of them who were killed.
A new website, www.glasgow.ac.uk/ww1, is being set up.
A university spokeswoman said: "Our archivists are keen to hear from alumni and others about those who served and died in the First World War, and also about those who were able to return home and begin afresh.
"The university's own archives already contain a rich trove of material relating to the 1914-1918 war."
Among the University's collection so far are slides and a scrap book from William Beardmore and Co, steel manufacturers and engineers from the Parkhead Forge in Glasgow's East End.
Beardmores made guns, ships and aeroplanes for the war effort. Information gathered so far can be found at http://www.universitystory.gla.ac.uk/ww1-intro/