Routes around the Athletes Village in the east end of the city will be severely restricted for security and logistical reasons. It is to be home to about 6500 competitors, their training teams and a 3600-strong workforce.
On Tuesday, Glasgow councillors will be asked to agree plans for the hub along with venues including the Emirates Arena, Tollcross Leisure Centre and Hampden Park. They are the first of 14 separate applications that will be considered by the council's planning committee.
The Games will run over 11 days of competition from July 24, 2014, with the Athletes Village opening on July 8 to competitors. From July 13 until it closes on August 6, the state-of-the art housing development will operate around the clock.
Glasgow planning chief Richard Brown said: "Despite the Village being operational for just over 28 days, the lead-in time will be a number of months." It will host around 6500 athletes and team officials and a 3600-strong workforce and will be the central hub for operations, logistics and transport."
Security will be tight round all the venues, with the Athletes Village protected by high-visibility police patrols and private security.
Fencing, which will be nearly 10ft high in places, will surround the entire site.
It will be made of anti-climb mesh, which will be mounted on vehicle crash barriers and lit up at night.
Residents can expect additional noise and the site to be floodlit 24 hours a day.